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Richard Marais Selected Research

gamma-Glutamyl Hydrolase (Carboxypeptidase G2)

7/2008Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.
5/2007Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.
6/2005Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.
3/2002Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.

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Richard Marais Research Topics

Disease

74Melanoma (Melanoma, Malignant)
01/2022 - 06/2002
66Neoplasms (Cancer)
07/2021 - 03/2002
9Neoplasm Metastasis (Metastasis)
11/2018 - 10/2009
5Carcinogenesis
10/2017 - 01/2010
5Carcinoma (Carcinomatosis)
01/2011 - 03/2002
3Colorectal Neoplasms (Colorectal Cancer)
09/2015 - 08/2010
3Aneuploidy (Aneuploid)
10/2013 - 11/2010
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2013 - 08/2011
3Sarcoma (Soft Tissue Sarcoma)
09/2010 - 06/2008
2Inflammation (Inflammations)
09/2015 - 08/2011
2Thyroid Neoplasms (Thyroid Cancer)
05/2013 - 08/2011
2Hypopigmentation (Hypomelanosis)
09/2010 - 10/2009
1Adenocarcinoma of Lung
10/2017
1Hypoxia (Hypoxemia)
08/2015
1Pancreatic Neoplasms (Pancreatic Cancer)
08/2015

Drug/Important Bio-Agent (IBA)

20Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
10/2017 - 04/2004
16Pharmaceutical PreparationsIBA
07/2019 - 06/2005
12Phosphotransferases (Kinase)IBA
10/2017 - 03/2004
8Protein Kinases (Protein Kinase)IBA
03/2014 - 08/2004
7Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2018 - 06/2002
6Transcription Factors (Transcription Factor)IBA
01/2019 - 04/2004
6Protein Isoforms (Isoforms)IBA
10/2017 - 10/2004
6PLX 4720IBA
12/2016 - 12/2009
6VemurafenibIBA
12/2016 - 01/2012
6Proteins (Proteins, Gene)FDA Link
03/2013 - 04/2004
5EnzymesIBA
12/2020 - 03/2002
4T-Cell Antigen Receptors (T-Cell Receptor)IBA
01/2022 - 01/2020
4Serine (L-Serine)FDA Link
09/2010 - 08/2004
4Threonine (L-Threonine)FDA Link
09/2010 - 08/2004
4ProdrugsIBA
07/2008 - 03/2002
4gamma-Glutamyl Hydrolase (Carboxypeptidase G2)IBA
07/2008 - 03/2002
4Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
12/2005 - 08/2005
3Biomarkers (Surrogate Marker)IBA
01/2022 - 07/2013
3Immune Checkpoint InhibitorsIBA
01/2022 - 12/2020
3DNA (Deoxyribonucleic Acid)IBA
01/2020 - 08/2004
3RNA (Ribonucleic Acid)IBA
01/2020 - 04/2004
3Proto-Oncogene Proteins B-rafIBA
01/2019 - 07/2009
3Microphthalmia-Associated Transcription FactorIBA
10/2014 - 08/2005
3Telomerase (Telomerase Reverse Transcriptase)IBA
06/2011 - 06/2005
2Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA
12/2020 - 01/2019
2Biological ProductsIBA
12/2020 - 11/2004
2dabrafenibIBA
01/2020 - 02/2013
2CollagenIBA
01/2019 - 06/2014
2CopperIBA
01/2019 - 09/2010
2Transforming Growth Factors (Transforming Growth Factor)IBA
12/2016 - 01/2013
2Transforming Growth Factor beta (TGF-beta)IBA
12/2016 - 10/2009
2Lactic Acid (Lactate)FDA LinkGeneric
12/2016 - 07/2013
2Mitogen-Activated Protein KinasesIBA
03/2016 - 01/2013
2CateninsIBA
01/2016 - 08/2015
2ActomyosinIBA
06/2014 - 08/2011
2NucleotidesIBA
10/2013 - 02/2012
2Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
03/2013 - 06/2010
2MitogensIBA
03/2013 - 04/2004
2ErbB Receptors (EGF Receptor)IBA
02/2013 - 03/2007
22- (2- chloro- 4- iodophenylamino)- N- cyclopropylmethoxy- 3,4- difluorobenzamideIBA
01/2013 - 12/2009
2Metformin (Glucophage)FDA LinkGeneric
07/2012 - 04/2012
2Sorafenib (BAY 43-9006)FDA Link
08/2011 - 06/2010
2tanespimycin (17AAG)IBA
04/2008 - 12/2005
2beta-Galactosidase (Lactaid)IBA
04/2003 - 03/2002
1ParaffinIBA
01/2022
1Formaldehyde (Formol)FDA Link
01/2022
1NivolumabIBA
01/2020
1Cell-Free Nucleic AcidsIBA
01/2020
1cyclopropapyrroloindoleIBA
01/2020
1AminesIBA
01/2019
1ElastinIBA
01/2019
1Oxidoreductases (Dehydrogenase)IBA
01/2019
1capivasertibIBA
01/2018
1Transforming Growth Factor-beta Type I ReceptorIBA
12/2016
1Pyruvic Acid (Pyruvate)IBA
12/2016
1Nelfinavir (Viracept)FDA Link
03/2016
1PoisonsIBA
01/2016
1Glutamine (L-Glutamine)FDA Link
01/2016
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
09/2015
1Dinoprostone (PGE2)FDA Link
09/2015
1Prostaglandin-E SynthasesIBA
09/2015
1Messenger RNA (mRNA)IBA
08/2015
1Cadherins (E-Cadherin)IBA
08/2015
1Caveolin 1IBA
08/2015
1GemcitabineFDA Link
08/2015
1Fibrillar CollagensIBA
08/2015
1IntegrinsIBA
04/2015
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2014
1Cytotoxins (Cytolysins)IBA
09/2014
1Sunscreening Agents (Sunscreens)IBA
07/2014
1GelatinasesIBA
06/2014
1Collagenases (Collagenase)FDA Link
06/2014
1Matrix Metalloproteinases (MMPs)IBA
06/2014
1Interleukin-8 (Interleukin 8)IBA
03/2014
1Peptide Hydrolases (Proteases)FDA Link
03/2014
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
03/2014
1Celecoxib (Celebrex)FDA Link
03/2014
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
03/2014
1AgarIBA
03/2014
1trametinibIBA
03/2014

Therapy/Procedure

25Therapeutics
10/2021 - 01/2005
5Immunotherapy
01/2022 - 07/2012
4Precision Medicine
07/2021 - 05/2013
2Drug Therapy (Chemotherapy)
01/2017 - 08/2015
1Radiotherapy
10/2013